Ganesh Remedies Expertise in Acid Chlorides Manufacturing: Cyclopropanecarbonyl chloride

SGRL has broad expertise in handling of the following reactions and processes. We can undertake custom/contract manufacture for you.

· Chlorination

· Grignard Reactions

· Hydrogenation / Reduction

· Oxidation

· Bromination

· Esterification

Chlorination:

Carboxylic acids react with Thionyl Chloride (SOCl2) to form Acid chlorides. During the reaction the hydroxyl group of the carboxylic acid is converted to a chlorosulfite intermediate making it a better leaving group. The chloride anion produced during the reaction acts a nucleophile.

Products of Shree Ganesh Remedies Limited in Acid Chlorides

2-Furoyl chloride CAS 527-69-5

4-Chlorobutyryl chloride CAS 4635-59-0

2-Furoic acid CAS 88-14-2

O-Acetylsalicyloyl chloride CAS 5538-51-2
Cyclopropanecarbonyl chloride CAS 4023-34-1

Mechanism of Chlorination to Manufacture Acid Chlorides

There is a distinct mechanism to make acid chlorides using thionyl chloride compounds. This mechanism, the process used to complete an acid chloride reaction, is called nucleophilic acyl substitution.

Let's break down the steps occurring in this reaction.

Step 1: We call the oxygen atom, in the alcohol group, a nucleophile. A nucleophile is a molecule or ion that will donate its electron pair to form a chemical bond. This nucleophile attacks the carbon atom, an electrophile, in the carbonyl group (CO). An electrophile is a molecule that accepts an electron pair to form a chemical bond. When the nucleophile attacks the electrophile, the result is an intermediate formed with our friend thionyl chloride.

Step 2: Following this attack, the intermediate collapses. This causes the removal of the chlorine atom as a leaving group from thionyl chloride. A leaving group is any fragment (molecule or atom) that leaves with its electrons. Once the leaving group is removed, a chlorosulfite ion is formed.

Step 3: A second nucleophilic attack on the carbonyl group of the chlorosulfite ion occurs. The chlorine atom, a leaving group, bonds to the carbon atom. Note that this carbon atom is an electrophile. Once bonded, an intermediate is formed.

Step 4: The leaving group is removed and intermediate collapses. This leads to the production of yet another intermediate.

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Cyclopropane carbonyl Chloride 4023-34-1

Bis(2-chloroethyl)amine hydrochloride CAS No : 821-48-7

Toll Manufacturing of CAS No: 1771-18-2 : 2-Methoxyphenothiazine